Episode 8/13: Nucleotides // A Course on Abiogenesis by Dr. James Tour

In this episode, Dr. James Tour educates on the 3rd class of compounds needed for life: nucleotides, comprised of a sugar (carbohydrate), a nucleobase, and a phosphate. With the reminder how manufacturers extract nucleotides from biological sources and how the oligomer synthesis cycle in solid phase DNA synthesis must use synthetically-prepared protective mechanisms, prebiotic nucleotide synthesis remains a mystery. Furthermore, it is revealed that the problem of sequence specific biological information—a world where order matters—remains unaddressed, with RNA World still looking incredibly unstable and bleak. Finally, with the secret of relay synthesis exposed, origin of life research faces a real challenge in the quest for prebiotic relevance, especially when these syntheses only provide nucleotides in racemic form and gross mixtures of diastereomers on the ribose. Video Index: 00:00 - Introduction 00:40 - Reasons & Intent of this Abiogenesis Series 02:17 - Nucleosides & Nucleotides 05:49 - Structure and Composition of DNA/RNA 08:58 - What was said about synthesis 11:40 - Solid Phase DNA Synthesis explained 17:19 - Prebiotic Relevance & Invoking Relay Synthesis 26:57 - "small molecules" to RNA - Never Been Shown 29:57 - Random Information vs Life's Functional Information 32:57 - Prebiotic Sequence Selection 35:18 - RNA Self-Replication 38:18 - Time & Molecular Degradation 48:48 - Summary and What's Next Links in this Series | Addressing Abiogenesis & Common Misconceptions ====== Series Trailer: https://youtu.be/N-RvMStTkx4 ------ 0 - Reasons for this Series: https://youtu.be/71dqAFUb-v0 1 - Introduction to Abiogenesis: https://youtu.be/NqoVxwdWWpg 2 - Primordial Soup: https://youtu.be/tNbl-g8QoAg 3 - Hype: https://youtu.be/Q6b76XQQN00 4 - Homochirality: https://youtu.be/tqbpd3CmBgE 5 - Carbohydrates: https://youtu.be/rdqd_EvpsZM 6 - Building Blocks of Building Blocks: https://youtu.be/rdqd_EvpsZM 7 - Peptides: https://youtu.be/0Hv6KjB0j8Y 8 - Nucleotides: https://youtu.be/CYiguQYCSio 9 - Intermediate Summary & a Call to Colleagues: https://youtu.be/ImPxfmKrmoY 10 - Lipids: https://youtu.be/QTQd5Ifqv2g 11 - Chiral-induced Spin Selectivity: https://youtu.be/VKEZSfuMgL0 12.1 - Cell Construction & The Assembly Problem, Part 1: https://youtu.be/IaJo5jWs_6k 12.2 - Cell Construction & The Assembly Problem, Part 2: https://youtu.be/fDayvhch_W4 13 - Summary & Projections: https://youtu.be/71GTCHkId6M DNA animations by wehi.edu.au: https://youtu.be/7Hk9jct2ozY Transcription - Central Dogma Part 1 by wehi.edu.au: https://youtu.be/DA2t5N72mgw Translation - Central Dogma Part 2 by wehi.edu.au: https://youtu.be/WkI_Vbwn14g Link to the cited video ("Elucidating the Agenda of James Tour: A Defense of Abiogenesis") can be found in the video description of Episode 0 - "Reasons for this Series" here: https://youtu.be/71dqAFUb-v0 The passionate thumbnail for this video uses a still frame image taken from Dr. Tour's video on Flash Graphene when he says "any" in the phrase "any carbon source" at 0:12: https://youtu.be/hhN5I_ocLSU If you found this helpful and a blessing to you or learned something new, please share and give this a like or thumbs up. And if you haven't already, please follow/like/subscribe, so you can stayed tuned in. God bless you. #Abiogenesis #JamesTour #OriginOfLife ~ http://drjamestour.com Website - http://jmtour.com Twitter - http://twitter.com/drjamestour Facebook - http://facebook.com/drjamestour LinkedIn - http://linkedin.com/in/drjamestour Instagram - http://instagram.com/drjamestour Snapchat - http://snapchat.com/add/drjamestour WeChat - @drjamestour