The microRNA Mystery Evolution Struggles to Explain

Royal Truman presents cells as sophisticated information-processing systems governed by biological codes, arguing that microRNA regulation depends on tightly coordinated digital-and-analog logic. The discussion challenges naturalistic origin scenarios by focusing on genome burden, misregulation, protein infrastructure, and population-genetics hurdles. RNA World Hypothesis Paper: https://www.researchgate.net/publication/405336423_The_RNA_World_Hypothesis_A_Critical_Reassessment_of_Prebiotic_Plausibility Featuring: Dr. James Tour Dr. Royal Truman Dr. Rob Stadler Dr. Onsi Fakhouri 00:00 Intro: just-so stories and biology 03:59 Enzymes, codes, and cellular control 07:25 Recognition elements and specificity factors 10:11 Variables, values, and E-box examples 13:28 Data structures in RNA and chromosomes 16:17 Queues, translation, and overlapping codes 19:25 Is cellular code only an analogy? 22:05 Analog programming and fuzzy variables 24:32 Continuous signals in cellular programs 26:46 How microRNA regulation works 30:07 Extra genome burden for microRNA origins 33:03 Random binding and harmful misregulation 36:23 Target counts and timing problems 39:09 Population genetics of fixation 43:55 Slightly harmful mutations rarely fix 45:54 Other biological codes face same issue 47:53 Digital and analog life compared 51:21 Small RNAs vs microRNA systems 53:35 Co-option stories and waiting-time math 56:20 Species-specific microRNA challenges 58:30 Cellular sensors and downstream events 1:01:17 Critique of simplified origin stories 1:04:37 Information transfer and complexity 1:07:04 Final reflections on cellular engineering --- If you’d like to support our work and help us create more content across all platforms, we’d be grateful for any contribution. 🙏 Learn how to give at jesusandscience.org/donate. God bless you! Donate: 💝 jesusandscience.org/donate Research Page: 🔬 jmtour.com Facebook: 📘 facebook.com/drjamestour Instagram: 📸 instagram.com/drjamestour X/Twitter: 🐦 x.com/drjamestour TikTok: 🎶 tiktok.com/@drjamestour YouTube: ▶️ ⁨@DrJamesTour⁩ Discord: 💬 https://discord.gg/zUgBMKjk2p